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ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will improve the amount or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has long been associated with coadministration of ritonavirfluvoxamine will raise the amount or impact of